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In spite of these observations, the therapeutic goal of reducing the blood pressure to target, regardless of agent used, should not be sacrificed.

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Some side effects may occur that usually do not need medical attention.

Investigator-reported events were independently adjudicated by the clinical committee reviewing end points at the Duke Clinical Research Institute (DCRI), whose members were unaware of patients' study-group assignments.

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Medication Guide and Patient Instructions for Use and should be informed that the Medication Guide is not a disclosure of all possible side effects.

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